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Causes for Gynecomastia

Androgen, also called androgenic hormones or testoids, is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the activity of the accessory male sex organs and development of male secondary sex characteristics.

Androgen Insensitivity Syndrome: Females with male XY genetics but inability to respond to testosterone.

Klinefelter syndrome: A genetic condition where males have at least one extra X chromosome or extra copies of both the X and Y chromosomes in each cell. Normally male cells contain one X and one Y chromosome in each cell. The condition is not inherited but is a result of problems during cell division. Klinefelter syndrome variants is a more severe form of the condition as it involves more than one extra X or X and Y chromosome in each cell.

Klinefelter syndrome: A common sex chromosomal anomaly in males characterized mainly by small testes with tubular hyalinization, azospermia with infertility, slight breast enlargement, elevated urinary gonadotropins, and decreased urinary 17-ketosteroids. Dull mentality has been noted. The affected individuals appear normal after birth, except for small testes. Most characteristic features become evident at adolescence as hypogonadism, gynecomastia, incomplete virilization with variable eunuchoidism, and dull mentality. Without testosterone therapy, most adult patients may become obese. Occasional abnormalities may include cryptorchidism, hypospadias, ataxia, scoliosis during adolescence, and diabetes mellitus in adulthood.

Seminiferous tubule dysgenesis: rarely used term for a disorder in which the seminiferous tubules exhibit an abnormal cytoarchitecture and extensive hyalinization; the testes are small, and few spermatozoa are formed; the body habitus may be eunuchoid, and gynecomastia may be present; urinary gonadotropin output is usually high, and the incidence of mental deficiency and illness increased; sex chromatin may be male or female, and androgen secretion ranges from subnormal to normal. It is a constant feature of (and the term may be used synonymously with) Klinefelter syndrome.

 

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