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Arthritis Patients Not Taking Gastroprotective Medication With NSAIDs/COX-2 Inhibitors at Increased Risk

By Carol Eustice, About.com Guide April 17, 2012


provailen, Arthritis Pain Relief, arthritis diet, arthritis in hands, lower back pain treatment, knee arthritis, degenerative arthritis Many arthritis patients take a nonsteroidal anti-inflammatory drug(NSAID) or COX-2 inhibitor to help manage their symptoms. It is known that these drugs are associated with an increased risk of gastrointestinal problems. Some doctors, according to current guidelines, recommend or prescribe gastroprotective agents (such as proton pump inhibitors or misoprostol) to decrease that risk.

Patients who don't stick with taking a gastroprotective agent along with their NSAID are at higher risk for upper gastrointestinal problems compared to patients who adhere to the regimen, according to previous studies. A study, published online April 16, 2012 in Arthritis & Rheumatism, concluded the same was true for patients taking COX-2 inhibitors. Less adherence correlated with more gastointestinal complications. Analysis showed that for every 10% decrease in adherence to the gastroprotective regimen (i.e., 3 days not taking gastroprotective medication out of 30 days), there was a 9% increase in risk of upper gastrointestinal complications. Problem is, PPIs have not been without warnings. As always, it's important to weigh the benefits and risk of treatment.

 

Source : http://arthritis.about.com/b/2012/04/17/arthritis-patients-not-taking-gastroprotective-medication-with-nsaidscox-2-inhibitors-at-increased-risk.htm

 


 

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